Ian Wilson's lab at The Scripps Research Institute
reports the structure of the receptor-binding domain (RBD) of the
SARS-CoV-2 spike protein with a bound Fab fragment of the human
neutralizing antibody CR3022. CR3022, isolated more than 15 years ago
from a convalescent SARS patient, targets a highly conserved epitope on
Crystal structure of CR3022 in complex with SARS-CoV-2 RBD.
(A) Overall topology of the SARS-CoV-2 spike glycoprotein. NTD: N-terminal
domain, RBD: receptor-binding domain, SD1: subdomain 1, SD2: subdomain 2,
FP: fusion peptide, HR1: heptad repeat 1, HR2: heptad repeat 2, TM:
transmembrane region, IC: intracellular domain.
(B) Structure of CR3022 Fab in complex with SARS-CoV-2 RBD. CR3022 heavy
chain is colored in orange, CR3022 light chain in yellow, and SARS-CoV-2
RBD in light grey.
(C-D) Epitoperesidues on SARS-CoV-2 are colored in cyan and green. CDR
loops are labeled.
M. Yuan, N.C. Wu, X. Zhu, C.D. Lee, R.T.Y. So, H. Lv, C.K.P. Mok,
I.A. Wilson, Science, 03 April 2020,
the Scripps Institute News Report.
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