Experiments at the GM/CA beamlines have resulted in many world-class results in the field of molecular biology. Here are some excerpts from the users works of GM/CA @ APS:

 

GM/CA-user highlights (APS and other)

2025  2024  2023  2022  2021  2020  2019  2018  2017  2016  2015  2014  2013  2012  2011  2010  2009  2008  2007  2006 
2025
Newly created molecules block cytokine storm
Shaping the future of antibiotic design
How Enzymes Make New Products Using Greenhouse Gases
2024
Gut enzymes may explain differential disease and FDA-approved drug outcomes
A minimal antiviral-protein complex binds and degrades single-stranded RNA. Melanie Ohi and Janet Smith groups (University of Michigan) and Paul Bieniasz group (Rockefeller University)
APOBEC3G non-catalytic domain mystery solved. Xiaojiang Chen group (University of Southern California)
Nobel Prize winner conducted protein folding research at Advanced Photon Source, Argonne supercomputers
The divergent human astrovirus VA1 capsid spike protein. Rebecca Dubois group (University of California, Santa Cruz)
Novel plant cyclic peptide biosynthesis could lead to new therapeutics
The Crossroads between synthetic DNA and understanding the origins of life
Finding the key to a Malaria vaccine
Vaccine regimen induces antibodies that can prevent HIV infection
2023
A high-resolution structure of a durable triple-antibody cocktail to treat Ebola virus infection. Erica Ollmann Saphire group (La Jolla Institute for Immunology)
Transient water wires in designed channel proteins. William DeGrado group (University of California, San Francisco) and Gregory Voth group (University of Chicago)
Architecture of a human nanoassembly for B(12) delivery and repair. Ruma Banerjee group (University of Michigan)
Modulation of the adhesion GPCR ADGRL3/Latrophilin3 by a synthetic binder. Demet Araç group (The University of Chicago)
T Cell Recognition of a Dominant SARS-CoV-2 Nucleocapsid Epitope. Roy Mariuzza (University of Maryland) and Nan-ping Weng (National Institute on Aging, NIH) groups
Structure of full-length cobalamin-dependent methionine synthase. Markos Koutmos group (University of Michigan).
A new approach to fighting malaria seeks to block transmission from humans to mosquitoes
Scientists create antibody 'cocktail' to fight deadly Lassa virus.
Treating COVID-19 by Inhibiting Viral Replication.
For Some Drugs, One Water Molecule Makes All the Difference
2022
Defining How a "Toxin Sponge" Found in Frogs and Toads Halts a Deadly Neurotoxin.
Engineering Enzymes to Tackle Plastic Waste.
Putting the Brakes on "Budding" Viruses.
Mutations Mislead Glial Cells into Dangerous Activity.
Microbes in the Gut Drive Toxicity of Environmental Chemical.
Using X-rays to Decode a Complex Piece of Cellular Machinery, Atom by Atom.
Plastic-eating Enzyme Could Eliminate Billions of Tons of Landfill Waste.
Finding New Ways to Treat Diabetes and Other Inflammatory Diseases.
2021
A Template for Inhibiting SARS-CoV-2 Replication.
First Detailed Look at a Crucial Enzyme Advances Cancer Research.
Never-Before-Seen Antibody Binding, Informing Liver Cancer Antibody Design.
Synthesis of a Potent Antibiotic Follows an Unusual Chemical Pathway.
New Promising Antibodies against SARS-CoV-2.
How One Antibody Blocks Dangerous Effects of Dengue Virus Infection: A Potential Path to Prevention.
2020
100th Structure of COVID-19 Virus from Advanced Photon Source Data Released.
A Scientific First: How Psychedelics Bind to Key Brain Cell Receptor.
Mamba Snake Toxin Unlocks Potential for Future Drug Discoveries.
A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2 and SARS-CoV. Ian Wilson group (Scripps Research Institute) and collaborators.
Structurally distinct active conformations within a GPCR. Robert Lefkowitz group (Duke University) and Andrew Kruse group (Harvard Medical School).
Structural basis for adhesion G protein-coupled receptor Gpr126 function. Demet Araç group (University of Chicago) and collaborators.
2019
Newly Discovered Antibody May Protect against Wide-Ranging Flu Strains.
How Fungi Produce Compounds with Potential Pharmaceutical Applications.
First Pictures of an Enzyme that Drives a New Class of Antibiotics.
Toward a universal therapy against Ebola virus.
Structurally distinct active conformations within a GPCR. Matt Whorton group (Oregon Health & Science University).
Aiming for pan-Lassa virus neutralization. Erica Saphire group (La Jolla Institute for Immunology).
The Smoothened receptor in an activated state. Aashish Manglik group (University of California, San Francisco).
Activation of metabotropic glutamate receptors. Brian Kobilka and George Skiniotis groups (Stanford University) and collaborators.
Antitumor activity of multispecific frizzled antibodies. Jean-Philippe Julien group (Hospital for Sick Children Research Institute; University of Toronto) and collaborators.
Topological Control of Cytokine Receptor Signaling. Chris Garcia group (Stanford University), David Baker group (University of Washington), and Vijay Sankaran group (Harvard Medical School).
Constructing an Anti-Cancer Drug. Amie Boal group (Penn State University) and Emily Balskus group (Harvard University).
Structural basis for angiotensin receptor activation. Robert Lefkowitz group (Duke University) and Andrew Kruse group (Harvard Medical School).
Molecular basis of synaptic specificity. Engin Özkan and Robert Carillo groups (University of Chicago).
The cardiac Ryanodine receptor phosphorylation hot spot embraces PKA. Filip Van Petegem group (University of British Columbia).
2018
A potential new approach to prevent Influenza virus infections.
Rare antibodies show how to neutralize the many types of Ebola.
How "Gatekeepers" to a Cell's Nucleus Let Genetic Instructions Pass Through.
Determining the structure of a protein associated with inflammation and Parkinson's.
Structure of a naturally-occurring anion channelrhodopsin. The groups of Karl Deisseroth and Brian Kobilka (Stanford University) and collaborators.
Selectivity and Gating in Anion Channelrhodopsins. The groups of Karl Deisseroth and Brian Kobilka (Stanford University) and collaborators.
Class Ie Ribonucleotide Reductase (RNR) from Pathogens. Amie Boal group (Penn State University) and collaborators.
Structure of RodA via evolutionary coupling analysis. Andrew Kruse group (Harvard University) and collaborators.
Smoothened activation in Hedgehog signaling. Adrian Salic and Andrew Kruse groups (Harvard Medical School).
Risperidone complexed with the D2-dopamine receptor. Bryan Roth group (University of North Carolina Chapel Hill) and collaborators.
Active-state structure of the kappa opioid receptor. Bryan Roth group (University of North Carolina Chapel Hill) and collaborators.
A human tachykinin receptor. Dan Rosenbaum group (UT Southwestern Medical Center).
Arrhythmia mutations in calmodulin affect interactions with the cardiac voltage-gated calcium channel. Filip Van Petegem group (University of British Columbia).
Human monoclonal antibodies prevent Zika virus escape mutations. Pamela Bjorkman group (California Institute of Technology) and collaborators.
2017
A key psychiatric drug target comes into focus.
Form reveals function in new study of HIV-fighting protein.
Crystallizing the Discovery of a Key Target for Cancer Drugs.
The First Crystal Model of an Under-Diagnosed Autoimmune Disease.
Jumping a Hurdle in HIV Vaccine Design.
The Science of the Circadian Clock.
How LSD Attaches to a Brain-Cell Serotonin Receptor.
Structure of a mechano- and thermo-sensitive potassium channel reveals a cryptic selectivity filter binding site. Daniel Minor group (University of California San Francisco).
Structure of the potassium-importing KdpFABC membrane complex. David Stokes group (New York University).
Structure and function of a divalent anion/Na+ symporter. Min Lu group (Rosalind Franklin University).
Fighting retinoblastoma. Seth Rubin group (University of California, Santa Cruz).
A novel tetrameric potassium channel. Youxing Jiang group (University of Texas Southwestern Medical Center).
Structure of the envelope glycoprotein (Env) from HIV Clade C. Ian Wilson group (The Scripps Research Institute) and collaborators.
Peptides inhibit influenza virus fusion. Ian Wilson group (The Scripps Research Institute) and collaborators.
Arbidol inhibition of influenza virus fusion. Ian Wilson group (The Scripps Research Institute).
The Notch-Jagged complex structure. Chris Garcia group (Stanford University).
Force activation of TGF-β. Tim Springer group (Harvard University).
2016
GM/CA@APS user Harry Noller wins the 2016 "Breakthrough Prize" in life sciences.
The Most Detailed Model of the Brain Receptor Behind Marijuana's High.
Bob Fischetti (GM/CA-XSD) on Zika Research at the APS.
Researchers Determine Key Zika Virus Structure.
Determining the 3-D Atomic Structure of a Cholesterol Transporter.
Unfolding the Mystery of the Nuclear Pore Complex.
A New Approach to Treating Atherosclerosis.
A radical S-adenosylmethionine enzyme caught in the act of modifying tRNA. Amy Boal and Squire Booker groups (Pennsylvania State University).
Antagonizing oncogenic Ras. Arvin Dar group (Icahn School of Medicine at Mount Sinai).
Non-ribosomal peptide synthetases. Andrew Gulick group (Hauptman-Woodward Institute).
Structure of the human σ1 receptor. Andrew Kruse group (Harvard University).
The structure of a Human Tetraspanin Reveals a Cholesterol-Binding Pocket. Stephen Blacklow and Andrew Kruse groups (Harvard University).
Temperature-Sensitive Domain Controls Voltage-Gated Channel Activation. Dan Minor group (UCSF).
Conformational Plasticity in a Transsynaptic Adhesion Complex. Engin Ozkan group (University of Chicago).
HIV-1 Vpr steers human UNG2 toward destruction. Guillermo Calero group (University of Pittsburgh) and collaborators.
Decoding the netrin-1/UNC5 interaction and its therapeutical implications in cancers. Joerg Stetefeld group (University of Manitoba).
Structural basis of globomycin activity. Martin Caffrey group (Trinity College Dublin).
Structure of the faustovirus capsid. Michael Rossmann group (Purdue University).
The bestrophin ion channel. Steve Long group (Memorial Sloan Kettering Cancer Center).
Structure of a chemokine receptor with bound orthosteric and allosteric antagonists. Tracy Handel group (UC San Diego) and collaborators.
A substrate-engaged SecY protein-translocation channel. Tom Rapoport group (Harvard University).
2015
Solving a Major Piece of a Cellular Mystery.
Crystal Clear Images of Hormone Receptors.
A New Close-Up View of a Key Part of the Ebola Virus Life Cycle.
The Mysterious "Mimivirus" is Not So Mysterious Anymore.
A Key Cellular Gatekeeper.
Pictured Together for the First Time: a Chemokine and its Receptor.
Structural insights into μ-opioid receptor activation. Brian Kobilka group (Stanford University).
A polypeptide processing and secretion transporter. Jue Chen group (Rockefeller University).
A broadly neutralizing antibody against HIV. Pam Bjorkman group (California Institute of Technology).
The Chemokine receptor, US28. Chris Garcia group (Stanford University).
Structures of lysosomal phospholipase A2, important in cholesterol metabolism. John Tesmer group (University of Michigan) and collaborators.
Structure of human DNA pol theta - a role in breast cancer. Sylvie Doublie group (University of Vermont).
Structure of TSPO. Shelagh Ferguson-Miller group (Michigan State University).
2014
Blueprints of a Bacterial Infection.
Structures of Adenovirus cement proteins. Vijay Reddy and Glen Nemerow (The Scripps Research Institute).
Structure of the human subtype 2 orexin receptor (OX2R). Daniel Rosenbaum group (University of Texas Southwest Medical Center).
Structure of the diabetes-related human receptor protein GPR40. Gyorgy Snell group (Takeda pharmaceutical company).
The smoothened receptor. Ray Stevens group (The Scripps Research Institute) and collaborators.
Structure of a Class C GPCR metabotropic glutamate receptor. Ray Stevens group (The Scripps Research Institute) and collaborators.
Icosahedral bacteriophage Phi X174 forms a tail for DNA transport during infection. Michael Rossmann group (Purdue University) and collaborators.
2013
The Most Detailed Picture Yet of a Key AIDS Protein.
How HIV Infects Cells.
A Key Target for Diabetes Drugs.
How Serotonin Receptors Can Shape Drug Effects, from LSD to Migraine Medication.
Structure of a conserved regulator of cyclin-dependent kinase (CDK). Seth Rubin group (University of California - Santa Cruz).
Structure of a maltose transporter in complex with regulatory proteins. Jue Chen group (Purdue University).
Structural Rearrangement of Ebola Virus VP40 Yields Multiple Functions in the Virus Life Cycle. Erica Ollmann Saphire group (The Scripps Research Institute) and collaborators.
Adrenaline-activated structure of the beta 2 adrenoceptor stabilized with an engineered nanobody. Brian Kobilka group (Stanford University) and collaborators.
Activation and allosteric modulation of a muscarinic acetylcholine receptor. Brian Kobilka group (Stanford University) and collaborators.
The structure of beta-arrestin. Brian Kobilka group (Stanford University) and collaborators.
First crystal structure of a true glucose transporter. Jun-Yong Choe group (Rosalind Franklin University).
Translocation intermediate in cellulose synthesis and transport. Jochen Zimmer group (University of Virginia).
New Crystal Structure Helps Explain 50 Years of Research on a Novel Membrane Enzyme in E. coli. Martin Caffrey group (Trinity College Dublin).
First structure of a eukaryotic phosphate transporter revealed. Robert Stroud group (University of California - San Francisco) and collaborators.
Epigenetics. Yawen Bai group (National Cancer Institute, NIH) and collaborators.
HIV immunogen design using structural biology and nanotechnology. Ian Wilson group (The Scripps Research Institute) and collaborators.
Structure of a monotropic membrane enzyme. Michael Malkowski group (Hauptman-Woodward Medical Research Institute and SUNY - Buffalo) and collaborators.
Serotonin receptors. Ray Stevens group (The Scripps Research Institute) and collaborators.
Structure of a GPCR bound to an anti-tumor agent. Ray Stevens group (The Scripps Research Institute) and collaborators.
Mammalian GIRK2-βγ G-protein complex. Rod MacKinnon group (The Rockefeller University).
2012
Architecture and Viral Disease.
Outsmarting Flu Viruses.
Computer-Designed Proteins to Disarm a Variety of Flu Viruses.
Muscarinic acetylcholine receptors. Brian Kobilka group (Stanford University) and collaborators.
Structures of mu-opioid and delta-opioid receptors. Brian Kobilka group (Stanford University) and collaborators.
Structure of a protease-activated GPCR. Brian Kobilka group (Stanford University) and collaborators.
Ubiquitination complex plays a role in DNA repair. Cynthia Wolberger group (The Johns Hopkins University).
Yeast mitochondrial proton turbine. David Mueller group (Rosalind Franklin University) and collaborators.
An immune response to bacterial invasion. Ian Wilson group (The Scripps Research Institute) and collaborators.
Tackling drug resistance in chemotherapy. Jue Chen group (Purdue University).
Structure of neurotensin receptor NTS1. Reinhard Grisshammer group (The National Institutes of Health) and collaborators.
Structure of the human two-pore domain potassium ion channel TRAAK. Rod MacKinnon group (The Rockefeller University).
Structures of kappa-opioid and nociceptin/orphanin FQ receptors. Ray Stevens group (The Scripps Research Institute) and collaborators.
Structure of a GPCR target for multiple sclerosis treatment. Ray Stevens group (The Scripps Research Institute) and collaborators.
High-resolution structure of an adenosine receptor. Ray Stevens group (The Scripps Research Institute) and collaborators.
DNA mismatch repair. Wei Yang group (The National Institutes of Health).
Structure of a sodium-ion/calcium-ion exchanger. Youxing Jiang group (University of Texas - Southwestern).
2011
How a Powerful Antibody Neutralizes HIV.
Sending a Message: How Receptors Talk to G Proteins.
New Clues for Asthma Treatment.
Nanobody-stabilized GPCR. Brian Kobilka and Bill Weis groups (Stanford University) and collaborators.
Structure of Mediator head module revealed. Yuichiro Takagi group (Indiana University School of Medicine) and collaborators.
Visualizing an Intermediate State of the Maltose Transporter. Jue Chen group (Purdue University).
Structural Basis for Methyl Transfer by a Radical SAM Enzyme. Amy Rosenzweig group (Northwestern University) and collaborators.
Designing antibodies to Influenza. Ian Wilson group (The Scripps Research Institute) and collaborators.
Complex formation in the M1-fibrinogen network. Partho Ghosh group (University of California, San Diego) and collaborators.
Allosteric activation of Protein Kinase C. James Hurley group (National Institutes of Health) and collaborators.
A structure of the Sindis virus capsid. Michael Rossmann group (Purdue University) and colleagues.
First structure of a protein-activated GPCR. Ray Stevens group (The Scripps Research Institute) and collaborators.
Jasmonate Perception. Ning Zheng group (University of Washington) and collaborators.
Oxidative Demethylation in crystallo. Chuan He group (University of Chicago) and collaborators.
Epigenetics. Ben Black group (University of Pennsylvania).
Synthesis of microbial natural products. George Phillips group (University of Wisconsin - Madison) and collaborators.
Towards an effective HIV vaccine. Ian Wilson group (The Scripps Research Institute) and collaborators.
Advances in crystallization in mesophases. Martin Caffrey group (Trinity College Dublin).
2010
How a Virus Prepares to Infect Cells.
At the Crossroads of Chromosomes.
Unveiling the Structure of Adenovirus.
The Structure of the "Swine Flu" Virus.
Beta adrenergic receptors. Brian Kobilka and Bill Weis groups (Stanford University) and collaborators.
Enzymology in the crystal. Carrie Wilmot group (University of Minnesota).
A 1.8-MDa SAGA complex. Cynthia Wolberger group (Johns Hopkins University) and collaborators.
Broadly reactive antibody neutralizes HIV-1. Ian Wilson group (The Scripps Research Institute) and collaborators.
Visual chromophore recycling. Krzysztof Palczewski group (Case Western Reserve University) and collaborators.
2009
Boron-Based Compounds Trick a Biomedical Protein.
The Crystal Structure of a Meta-stable Intermediate Particle in Virus Assembly.
A full-length potassium channel. Anthony Kossiakoff group (University of Chicago) and collaborators.
Identification of a nuclear receptor as a therapeutic target in parasitic nematodes. David Mangelsdorf group (University of Texas Southwestern Medical Center) and collaborators.
Myxopyronin inactivation of RNA polymerase. Dmitry Vassylyev group (University of Alabama) and collaborators.
A broadly neutralizing antibody to influenza virus. Ian Wilson group (The Scripps Research Institute) and collaborators.
ErbB2, a therapeutic target in cancer. Mark Lemmon group (University of Pennsylvania).
Genome ejection from mature bacteriophageT4 capsids during infection. Michael Rossmann group (Purdue University) and collaborators.
Repair of oxidative damage to DNA. Sylvie Doublié group (University of Vermont).
Cytochrome c Oxidase. Shelagh Ferguson-Miller group (Michigan State University).
2008
A Fruit-Fly Protein that Captures Tumor Growth Factors.
Striking Nano Gold.
A fence-like coat for the nuclear pore. Günter Blobel group (The Rockefeller University).
Terminating translation. Harry Noller group (University of California - Santa Cruz).
Stop codon recognition in translation termination. Harry Noller group (University of California - Santa Cruz).
A non-human glycan mediates human susceptibility to a bacterial toxin. Jamie Rossjohn group (Monash University) and collaborators.
DNA packaging into bacteriophageT4 procapsids. Michael Rossmann group (Purdue University) and collaborators.
Structure of a bacterial-cell-wall-degrading enzyme in the bacteriophage phi29 tail. Michael Rossmann group (Purdue University) and collaborators.
Parkinson's Disease and GPCRs. Ray Stevens group (The Scripps Research Institute).
Recognition of hemi-methylated DNA. Sirano Dhe-Paganon (University of Toronto) and collaborators.
Synthetic antibodies for crystallization of structured RNA. Anthony Kossiakoff group (University of Chicago) and collaborators.
A structure of a tyrosyl-tRNA synthetase splicing factor bound to a group I intron RNA. Barbara Golden group (Purdue University).
A designed ion channel. Chris Miller group (Brandeis University)
Membrane protein: Polysulfide reductase. Mika Jormakka group (University of New South Wales) and collaborators.
Telomere binding proteins. Ming Lei group (University of Michigan).
Structure of a kinase-bound inhibitor of melanoma growth and invasiveness. Ronen Marmorstein group (Wistar Institute).
Catechol O-methyltransferase. Ron Stenkamp and Bill Parson groups (University of Washington).
Adenovirus fibers. Vijay Reddy group (The Scripps Research Institute) and collaborators.
2007
Unveiling the Molecular Structure of the Target of Many Drugs.
The human β2-adrenergic G-protein-coupled receptor. Brian Kobilka, Bill Weis groups (Stanford University), and Ray Stevens, Peter Kuhn groups (The Scripps Research Institute) and collaborators.
Crystal structure of an enzyme involved in Gaucher disease. Greg Petsko and Dagmar Ringe groups (Brandeis University).
Crystal structure related to rheumatic autoimmune diseases. James Sacchettini group (Texas A&M University).
Structure of enzyme domain involved in synthesis of natural products. Janet Smith group (University of Michigan) and collaborators.
Structures from the SARS-CoV proteomics project. Peter Kuhn group (The Scripps Research Institute) and collaborators.
2006
Guests, and hosts, and microfluidics. Rustem Ismagilov group (University of Chicago).

ANL Press Releases highlighting studies at GM/CA

Jul, 2023: Researchers use Argonne X-rays to find the best antibodies.
May, 2023: Advanced Photon Source powers the search for broadly effective coronavirus antibody treatment.
Jul, 2022: Researchers use X-rays to decode complex piece of cellular machinery, atom by atom.
May, 2022: Always adapting: Scientists use Argonne's Advanced Photon Source to fight SARS-CoV-2 variants.
Jun, 2021: Advanced Photon Source helps reveal how antibodies bind a molecule linked to cancer.
Apr, 2021: Caught in the act: New data about COVID-19 virus's functions could aid in treatment designs.
Mar, 2021: Why the lovable llama might be a secret weapon against COVID-19.
Jan, 2021: Scientists find antibody that blocks dengue virus.
Nov, 2020: How scientists around the country are using the APS to fight COVID-19.
May, 2020: Argonne's COVID-19 research makes progress.
Jun, 2017: Argonne X-rays used to help identify a key Lassa virus structure.
Apr, 2016: Biochemists solve the structure of cell's DNA gatekeeper.
Feb, 2016: Scientists blueprint antimicrobial candidate with promise in stemming the onrushing post-antibiotic tide.
Mar, 2015: Improved understanding of protein complex offers insight into DNA replication initiation mechanism basics.
Sep, 2014: X-rays unlock a protein's SWEET side.
Jul, 2014: Unprecedented detail of intact neuronal receptor offers blueprint for drug developers.
Feb, 2014: Decoding dengue and West Nile: Researchers take steps toward control of growing public health problems.
May, 2013: New approach to vaccine design targets HIV and other fast-mutating viruses.
Oct, 2012: Advanced Photon Source lights the way to 2012 Chemistry Nobel.
Apr, 2012: How heroin works: Imaging opioid receptors in the brain.
Mar, 2009: Research could lead to more comprehensive flu vaccines.

 

See also:  List of GM/CA @ APS users publications.

 

 

GM/CA @ APS Sponsors: National Institute of General Medical Sciences (NIGMS) and National Cancer Institute (NCI) of the National Institutes of Health (NIH).

  APS is an Office of Science User Facility operated for the U.S. Department of Energy by Argonne National Laboratory

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