Experiments at the GM/CA beamlines have resulted in many world-class results in the field
of molecular biology. Here are some excerpts from the users works of GM/CA @ APS:
GM/CA users highlights |
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2020
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2016
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| 2020 |
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A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2 and SARS-CoV. Ian Wilson group (Scripps Research Institute) and collaborators. |
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Structurally distinct active conformations within a GPCR. Robert Lefkowitz group (Duke University) and Andrew Kruse group (Harvard Medical School). |
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Structural basis for adhesion G protein-coupled receptor Gpr126 function. Demet Araç group (University of Chicago) and collaborators. |
| 2019 |
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Structurally distinct active conformations within a GPCR. Matt Whorton group (Oregon Health & Science University). |
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Aiming for pan-Lassa virus neutralization. Erica Saphire group (La Jolla Institute for Immunology). |
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The Smoothened receptor in an activated state. Aashish Manglik group (University of California, San Francisco). |
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Activation of metabotropic glutamate receptors. Brian Kobilka and George Skiniotis groups (Stanford University) and collaborators. |
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Antitumor activity of multispecific frizzled antibodies. Jean-Philippe Julien group (Hospital for Sick Children Research Institute; University of Toronto) and collaborators. |
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Topological Control of Cytokine Receptor Signaling. Chris Garcia group (Stanford University), David Baker group (University of Washington), and Vijay Sankaran group (Harvard Medical School). |
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Constructing an Anti-Cancer Drug. Amie Boal group (Penn State University) and Emily Balskus group (Harvard University). |
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Structural basis for angiotensin receptor activation. Robert Lefkowitz group (Duke University) and Andrew Kruse group (Harvard Medical School). |
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Molecular basis of synaptic specificity. Engin Özkan and Robert Carillo groups (University of Chicago). |
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The cardiac Ryanodine receptor phosphorylation hot spot embraces PKA. Filip Van Petegem group (University of British Columbia). |
| 2018 |
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Structure of a naturally-occurring anion channelrhodopsin. The groups of Karl Deisseroth and Brian Kobilka (Stanford University) and collaborators. |
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Selectivity and Gating in Anion Channelrhodopsins. The groups of Karl Deisseroth and Brian Kobilka (Stanford University) and collaborators. |
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Class Ie Ribonucleotide Reductase (RNR) from Pathogens. Amie Boal group (Penn State University) and collaborators. |
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Structure of RodA via evolutionary coupling analysis. Andrew Kruse group (Harvard University) and collaborators. |
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Smoothened activation in Hedgehog signaling. Adrian Salic and Andrew Kruse groups (Harvard Medical School). |
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Risperidone complexed with the D2-dopamine receptor. Bryan Roth group (University of North Carolina Chapel Hill) and collaborators. |
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Active-state structure of the kappa opioid receptor. Bryan Roth group (University of North Carolina Chapel Hill) and collaborators. |
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A human tachykinin receptor. Dan Rosenbaum group (UT Southwestern Medical Center). |
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Arrhythmia mutations in calmodulin affect interactions with the cardiac voltage-gated calcium channel. Filip Van Petegem group (University of British Columbia). |
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Human monoclonal antibodies prevent Zika virus escape mutations. Pamela Bjorkman group (California Institute of Technology) and collaborators. |
| 2017 |
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Structure of a mechano- and thermo-sensitive potassium channel reveals a cryptic selectivity filter binding site. Daniel Minor group (University of California San Francisco). |
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Structure of the potassium-importing KdpFABC membrane complex. David Stokes group (New York University). |
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Structure and function of a divalent anion/Na+ symporter. Min Lu group (Rosalind Franklin University). |
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Fighting retinoblastoma. Seth Rubin group (University of California, Santa Cruz). |
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A novel tetrameric potassium channel. Youxing Jiang group (University of Texas Southwestern Medical Center). |
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Structure of the envelope glycoprotein (Env) from HIV Clade C. Ian Wilson group (The Scripps Research Institute) and collaborators. |
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Peptides inhibit influenza virus fusion. Ian Wilson group (The Scripps Research Institute) and collaborators. |
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Arbidol inhibition of influenza virus fusion. Ian Wilson group (The Scripps Research Institute). |
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The Notch-Jagged complex structure. Chris Garcia group (Stanford University). |
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Force activation of TGF-β. Tim Springer group (Harvard University). |
| 2016 |
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A radical S-adenosylmethionine enzyme caught in the act of modifying tRNA. Amy Boal and Squire Booker groups (Pennsylvania State University). |
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Antagonizing oncogenic Ras. Arvin Dar group (Icahn School of Medicine at Mount Sinai). |
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Non-ribosomal peptide synthetases. Andrew Gulick group (Hauptman-Woodward Institute). |
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Structure of the human σ1 receptor. Andrew Kruse group (Harvard University). |
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The structure of a Human Tetraspanin Reveals a Cholesterol-Binding Pocket. Stephen Blacklow and Andrew Kruse groups (Harvard University). |
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Temperature-Sensitive Domain Controls Voltage-Gated Channel Activation. Dan Minor group (UCSF). |
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Conformational Plasticity in a Transsynaptic Adhesion Complex. Engin Ozkan group (University of Chicago). |
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HIV-1 Vpr steers human UNG2 toward destruction. Guillermo Calero group (University of Pittsburgh) and collaborators. |
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Decoding the netrin-1/UNC5 interaction and its therapeutical implications in cancers. Joerg Stetefeld group (University of Manitoba). |
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Structural basis of globomycin activity. Martin Caffrey group (Trinity College Dublin). |
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Structure of the faustovirus capsid. Michael Rossmann group (Purdue University). |
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The bestrophin ion channel. Steve Long group (Memorial Sloan Kettering Cancer Center). |
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Structure of a chemokine receptor with bound orthosteric and allosteric antagonists. Tracy Handel group (UC San Diego) and collaborators. |
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A substrate-engaged SecY protein-translocation channel. Tom Rapoport group (Harvard University). |
| 2015 |
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Structural insights into μ-opioid receptor activation. Brian Kobilka group (Stanford University). |
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A polypeptide processing and secretion transporter. Jue Chen group (Rockefeller University). |
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A broadly neutralizing antibody against HIV. Pam Bjorkman group (California Institute of Technology). |
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The Chemokine receptor, US28. Chris Garcia group (Stanford University). |
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Structures of lysosomal phospholipase A2, important in cholesterol metabolism. John Tesmer group (University of Michigan) and collaborators. |
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The Chemokine receptor, CXCR4. Tracy Handel group (University of California - San Diego) and Ray Stevens group (The Scripps Research Institute). |
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Structure of human DNA pol theta - a role in breast cancer. Sylvie Doublie group (University of Vermont). |
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Structure of TSPO. Shelagh Ferguson-Miller group (Michigan State University). |
| 2014 |
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Structures of Adenovirus cement proteins. Vijay Reddy and Glen Nemerow (The Scripps Research Institute). |
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Structure of the human subtype 2 orexin receptor (OX2R). Daniel Rosenbaum group (University of Texas Southwest Medical Center). |
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Structure of the diabetes-related human receptor protein GPR40. Gyorgy Snell group (Takeda pharmaceutical company). |
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The smoothened receptor. Ray Stevens group (The Scripps Research Institute) and collaborators. |
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Structure of a Class C GPCR metabotropic glutamate receptor. Ray Stevens group (The Scripps Research Institute) and collaborators. |
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Icosahedral bacteriophage Phi X174 forms a tail for DNA transport during infection. Michael Rossmann group (Purdue University) and collaborators. |
| 2013 |
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Structure of a conserved regulator of cyclin-dependent kinase (CDK). Seth Rubin group (University of California - Santa Cruz). |
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Structure of a maltose transporter in complex with regulatory proteins. Jue Chen group (Purdue University). |
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Structural Rearrangement of Ebola Virus VP40 Yields Multiple Functions in the Virus Life Cycle. Erica Ollmann Saphire group (The Scripps Research Institute) and collaborators. |
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Adrenaline-activated structure of the beta 2 adrenoceptor stabilized with an engineered nanobody. Brian Kobilka group (Stanford University) and collaborators. |
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Activation and allosteric modulation of a muscarinic acetylcholine receptor. Brian Kobilka group (Stanford University) and collaborators. |
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The structure of beta-arrestin. Brian Kobilka group (Stanford University) and collaborators. |
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First crystal structure of a true glucose transporter. Jun-Yong Choe group (Rosalind Franklin University). |
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Translocation intermediate in cellulose synthesis and transport. Jochen Zimmer group (University of Virginia). |
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New Crystal Structure Helps Explain 50 Years of Research on a Novel Membrane Enzyme in E. coli. Martin Caffrey group (Trinity College Dublin). |
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First structure of a eukaryotic phosphate transporter revealed. Robert Stroud group (University of California - San Francisco) and collaborators. |
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Epigenetics. Yawen Bai group (National Cancer Institute, NIH) and collaborators. |
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HIV immunogen design using structural biology and nanotechnology. Ian Wilson group (The Scripps Research Institute) and collaborators. |
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Structure of a monotropic membrane enzyme. Michael Malkowski group (Hauptman-Woodward Medical Research Institute and SUNY - Buffalo) and collaborators. |
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Serotonin receptors. Ray Stevens group (The Scripps Research Institute) and collaborators. |
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Structure of a GPCR bound to an anti-tumor agent. Ray Stevens group (The Scripps Research Institute) and collaborators. |
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Mammalian GIRK2-βγ G-protein complex. Rod MacKinnon group (The Rockefeller University). |
| 2012 |
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Muscarinic acetylcholine receptors. Brian Kobilka group (Stanford University) and collaborators. |
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Structures of mu-opioid and delta-opioid receptors. Brian Kobilka group (Stanford University) and collaborators. |
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Structure of a protease-activated GPCR. Brian Kobilka group (Stanford University) and collaborators. |
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Ubiquitination complex plays a role in DNA repair. Cynthia Wolberger group (The Johns Hopkins University). |
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Yeast mitochondrial proton turbine. David Mueller group (Rosalind Franklin University) and collaborators. |
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An immune response to bacterial invasion. Ian Wilson group (The Scripps Research Institute) and collaborators. |
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Tackling drug resistance in chemotherapy. Jue Chen group (Purdue University). |
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Structure of neurotensin receptor NTS1. Reinhard Grisshammer group (The National Institutes of Health) and collaborators. |
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Structure of the human two-pore domain potassium ion channel TRAAK. Rod MacKinnon group (The Rockefeller University). |
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Structures of kappa-opioid and nociceptin/orphanin FQ receptors. Ray Stevens group (The Scripps Research Institute) and collaborators. |
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Structure of a GPCR target for multiple sclerosis treatment. Ray Stevens group (The Scripps Research Institute) and collaborators. |
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High-resolution structure of an adenosine receptor. Ray Stevens group (The Scripps Research Institute) and collaborators. |
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DNA mismatch repair. Wei Yang group (The National Institutes of Health). |
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Structure of a sodium-ion/calcium-ion exchanger. Youxing Jiang group (University of Texas - Southwestern). |
| 2011 |
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First structure of a complex between a G protein coupled receptor (GPCR) and its G protein revealed. Brian Kobilka group (Stanford University) and collaborators. |
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Nanobody-stabilized GPCR. Brian Kobilka and Bill Weis groups (Stanford University) and collaborators. |
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Structure of Mediator head module revealed. Yuichiro Takagi group (Indiana University School of Medicine) and collaborators. |
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Visualizing an Intermediate State of the Maltose Transporter. Jue Chen group (Purdue University). |
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Structural Basis for Methyl Transfer by a Radical SAM Enzyme. Amy Rosenzweig group (Northwestern University) and collaborators. |
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Designing antibodies to Influenza. Ian Wilson group (The Scripps Research Institute) and collaborators. |
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Complex formation in the M1-fibrinogen network. Partho Ghosh group (University of California, San Diego) and collaborators. |
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Allosteric activation of Protein Kinase C. James Hurley group (National Institutes of Health) and collaborators. |
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A structure of the Sindis virus capsid. Michael Rossmann group (Purdue University) and colleagues. |
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First structure of a protein-activated GPCR. Ray Stevens group (The Scripps Research Institute) and collaborators. |
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Jasmonate Perception. Ning Zheng group (University of Washington) and collaborators. |
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Oxidative Demethylation in crystallo. Chuan He group (University of Chicago) and collaborators. |
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Epigenetics. Ben Black group (University of Pennsylvania). |
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Synthesis of microbial natural products. George Phillips group (University of Wisconsin - Madison) and collaborators. |
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Towards an effective HIV vaccine. Ian Wilson group (The Scripps Research Institute) and collaborators. |
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Advances in crystallization in mesophases. Martin Caffrey group (Trinity College Dublin). |
| 2010 |
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Beta adrenergic receptors. Brian Kobilka and Bill Weis groups (Stanford University) and collaborators. |
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Enzymology in the crystal. Carrie Wilmot group (University of Minnesota). |
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A 1.8-MDa SAGA complex. Cynthia Wolberger group (Johns Hopkins University) and collaborators. |
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"Swine flu" virus similar to 1918 "Spanish flu" virus. Ian Wilson group (The Scripps Research Institute) and collaborators. |
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Broadly reactive antibody neutralizes HIV-1Beta adrenergic receptors. Ian Wilson group (The Scripps Research Institute) and collaborators. |
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Visual chromophore recycling. Krzysztof Palczewski group (Case Western Reserve University) and collaborators. |
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Structure of the human adenovirus capsid. Vijay Reddy group (The Scripps Research Institute) and collaborators. |
| 2009 |
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A full-length potassium channel. Anthony Kossiakoff group (University of Chicago) and collaborators. |
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Identification of a nuclear receptor as a therapeutic target in parasitic nematodes. David Mangelsdorf group (University of Texas Southwestern Medical Center) and collaborators. |
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Myxopyronin inactivation of RNA polymerase. Dmitry Vassylyev group (University of Alabama) and collaborators. |
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A broadly neutralizing antibody to influenza virus. Ian Wilson group (The Scripps Research Institute) and collaborators. |
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ErbB2, a therapeutic target in cancer. Mark Lemmon group (University of Pennsylvania). |
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Genome ejection from mature bacteriophageT4 capsids during infection. Michael Rossmann group (Purdue University) and collaborators. |
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Repair of oxidative damage to DNA. Sylvie Doublié group (University of Vermont). |
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Cytochrome c Oxidase. Shelagh Ferguson-Miller group (Michigan State University). |
| 2008 |
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A fence-like coat for the nuclear pore. Günter Blobel group (The Rockefeller University). |
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Terminating translation. Harry Noller group (University of California - Santa Cruz). |
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Stop codon recognition in translation termination. Harry Noller group (University of California - Santa Cruz). |
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A non-human glycan mediates human susceptibility to a bacterial toxin. Jamie Rossjohn group (Monash University) and collaborators. |
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DNA packaging into bacteriophageT4 procapsids. Michael Rossmann group (Purdue University) and collaborators. |
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Structure of a bacterial-cell-wall-degrading enzyme in the bacteriophage phi29 tail. Michael Rossmann group (Purdue University) and collaborators. |
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Parkinson's Disease and GPCRs. Ray Stevens group (The Scripps Research Institute). |
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Recognition of hemi-methylated DNA. Sirano Dhe-Paganon (University of Toronto) and collaborators. |
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Synthetic antibodies for crystallization of structured RNA. Anthony Kossiakoff group (University of Chicago) and collaborators. |
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A structure of a tyrosyl-tRNA synthetase splicing factor bound to a group I intron RNA. Barbara Golden group (Purdue University). |
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A designed ion channel. Chris Miller group (Brandeis University) |
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Membrane protein: Polysulfide reductase. Mika Jormakka group (University of New South Wales) and collaborators. |
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Telomere binding proteins. Ming Lei group (University of Michigan). |
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EGFR ligand sequestration by Argos. Mark Lemmon group (University of Pennsylvania). |
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Structure of a kinase-bound inhibitor of melanoma growth and invasiveness. Ronen Marmorstein group (Wistar Institute). |
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Catechol O-methyltransferase. Ron Stenkamp and Bill Parson groups (University of Washington). |
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Adenovirus fibers. Vijay Reddy group (The Scripps Research Institute) and collaborators. |
| 2007 |
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The human β2-adrenergic G-protein-coupled receptor. Brian Kobilka, Bill Weis groups (Stanford University), and Ray Stevens, Peter Kuhn groups (The Scripps Research Institute) and collaborators. |
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Crystal structure of an enzyme involved in Gaucher disease. Greg Petsko and Dagmar Ringe groups (Brandeis University). |
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Crystal structure related to rheumatic autoimmune diseases. James Sacchettini group (Texas A&M University). |
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Structure of enzyme domain involved in synthesis of natural products. Janet Smith group (University of Michigan) and collaborators. |
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Structures from the SARS-CoV proteomics project. Peter Kuhn group (The Scripps Research Institute) and collaborators. |
| 2006 |
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Guests, and hosts, and microfluidics. Rustem Ismagilov group (University of Chicago). |
ANL Press Releases highlighting studies at GM/CA |
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Jun, 2017: Argonne X-rays used to help identify a key Lassa virus structure. |
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Apr, 2016: Biochemists solve the structure of cell’s DNA gatekeeper. |
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Feb, 2016: Scientists blueprint antimicrobial candidate with promise in stemming the onrushing post-antibiotic tide. |
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Mar, 2015: Improved understanding of protein complex offers insight into DNA replication initiation mechanism basics. |
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Sep, 2014: X-rays unlock a protein's SWEET side. |
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Jul, 2014: Unprecedented detail of intact neuronal receptor offers blueprint for drug developers. |
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Feb, 2014: Decoding dengue and West Nile: Researchers take steps toward control of growing public health problems. |
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May, 2013: New approach to vaccine design targets HIV and other fast-mutating viruses. |
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Oct, 2012: Advanced Photon Source lights the way to 2012 Chemistry Nobel. |
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Apr, 2012: How heroin works: Imaging opioid receptors in the brain. |
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Mar, 2009: Research could lead to more comprehensive flu vaccines. |
APS Science Highlights based on studies at GM/CA |
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Aug, 2020: Mamba Snake Toxin Unlocks Potential for Future Drug Discoveries. |
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Nov, 2019: Newly Discovered Antibody May Protect against Wide-Ranging Flu Strains. |
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Sep, 2019: How Fungi Produce Compounds with Potential Pharmaceutical Applications. |
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Aug, 2019: First Pictures of an Enzyme that Drives a New Class of Antibiotics. |
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Mar, 2019: Toward a universal therapy against Ebola virus. |
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Nov, 2018: A potential new approach to prevent Influenza virus infections. |
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Sep, 2018: Rare antibodies show how to neutralize the many types of Ebola. |
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Jun, 2018: How "Gatekeepers" to a Cell's Nucleus Let Genetic Instructions Pass Through. |
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Mar, 2018: Determining the structure of a protein associated with inflammation and Parkinson's. |
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Nov, 2017: A key psychiatric drug target comes into focus. |
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Oct, 2017: Form reveals function in new study of HIV-fighting protein. |
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Oct, 2017: Crystallizing the Discovery of a Key Target for Cancer Drugs. |
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Sep, 2017: The First Crystal Model of an Under-Diagnosed Autoimmune Disease. |
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Jun, 2017: Jumping a Hurdle in HIV Vaccine Design. |
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Mar, 2017: The Science of the Circadian Clock. |
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Jan, 2017: How LSD Attaches to a Brain-Cell Serotonin Receptor. |
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Dec, 2016: GM/CA@APS user Harry Noller wins the 2016 “Breakthrough Prize” in life sciences. |
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Nov, 2016: The Most Detailed Model of the Brain Receptor Behind Marijuana’s High. |
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Aug, 2016: Bob Fischetti (GM/CA-XSD) on Zika Research at the APS. |
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Jul, 2016: Researchers Determine Key Zika Virus Structure. |
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Jun, 2016: Determining the 3-D Atomic Structure of a Cholesterol Transporter. |
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Mar, 2016: Unfolding the Mystery of the Nuclear Pore Complex. |
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Feb, 2016: A New Approach to Treating Atherosclerosis. |
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Sep, 2015: Solving a Major Piece of a Cellular Mystery. |
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Aug, 2015: Crystal Clear Images of Hormone Receptors. |
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Jun, 2015: A New Close-Up View of a Key Part of the Ebola Virus Life Cycle. |
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May, 2015: The Mysterious "Mimivirus" is Not So Mysterious Anymore. |
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Feb, 2015: A Key Cellular Gatekeeper. |
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Jan, 2015: Pictured Together for the First Time: a Chemokine and its Receptor. |
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Aug, 2014: Blueprints of a Bacterial Infection. |
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Nov, 2013: The Most Detailed Picture Yet of a Key AIDS Protein. |
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Sept, 2013: How HIV Infects Cells. |
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Jul, 2013: A Key Target for Diabetes Drugs. |
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May, 2013: How Serotonin Receptors Can Shape Drug Effects, from LSD to Migraine Medication. |
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Nov, 2012: Architecture and Viral Disease. |
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Oct, 2012: Outsmarting Flu Viruses. |
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Jun, 2012: Computer-Designed Proteins to Disarm a Variety of Flu Viruses. |
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Oct, 2011: How a Powerful Antibody Neutralizes HIV. |
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Aug, 2011: Sending a Message: How Receptors Talk to G Proteins. |
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Mar, 2011: New Clues for Asthma Treatment. |
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Dec, 2010: How a Virus Prepares to Infect Cells. |
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Sep, 2010: At the Crossroads of Chromosomes. |
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Sep, 2010: Unveiling the Structure of Adenovirus. |
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Mar, 2010: The Structure of the "Swine Flu" Virus. |
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Sep, 2009: Boron-Based Compounds Trick a Biomedical Protein. |
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Mar, 2009: The Crystal Structure of a Meta-stable Intermediate Particle in Virus Assembly. |
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May, 2008: A Fruit-Fly Protein that Captures Tumor Growth Factors. |
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Feb, 2008: Striking Nano Gold. |
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Dec, 2007: Unveiling the Molecular Structure of the Target of Many Drugs. |
