NIGMS and NCI fund GM/CA@APS to provide cutting-edge beamlines that enable structural biologists to address challenging biomedical problems. We are pleased to announce receipt of a Notice of Award from NIGMS for a P30 grant to operate, maintain, and further enhance the beamlines for next 5 years.
GM/CA@APS delivers advanced macromolecular crystallography at two insertion-device beamlines (23-ID-B and 23-ID-D) of the Advanced Photon Source. A recent upgrade of optics, endstations, computing, motion control, and data acquisition was completed in parallel with the APS source upgrade. The new optics, combined with the upgraded APS, provide a brilliant micro-focused beam (1-50 µm) that is 1,000 times brighter across a wide energy range (5-35 keV).
High-precision goniometry and state-of-the-art detectors (Eiger X 16M, CdTe Eiger2 XE 16M) enable frame rates up to 560 Hz. The beamlines offer a powerful environment for sample screening, evaluation, data collection, and analysis. Users can tailor beam properties for microcrystallography, enabling the collection of data from weakly diffracting microcrystals.
PyBluIce provides intuitive beamline and sample control, including energy scans, rastering, and automated data collection. Rastering pinpoints microcrystals or the best-diffracting regions of larger crystals, with data processed in near real time. Serial crystallography with injectors and fixed-target sample mounts is also fully integrated into PyBluIce.
GM/CA @ APS
